Tuning L-Type Ca2+ Current Properties to Suppress Early After depolarizations
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چکیده
منابع مشابه
Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations
Early afterdepolarizations (EADs) associated with prolongation of the cardiac action potential (AP) can create heterogeneity of repolarization and premature extrasystoles, triggering focal and reentrant arrhythmias. Because the L-type Ca(2+) current (ICa,L) plays a key role in both AP prolongation and EAD formation, L-type Ca(2+) channels (LTCCs) represent a promising therapeutic target to norm...
متن کاملThe role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations.
Certain signaling events that promote L-type Ca2+ channel (LCC) phosphorylation, such as beta-adrenergic stimulation or an increased expression of Ca(2+)/calmodulin-dependent protein kinase II, promote mode 2 gating of LCCs. Experimental data suggest the hypothesis that these events increase the likelihood of early after-depolarizations (EADs). We test this hypothesis using an ionic model of th...
متن کاملTargeting the late component of the cardiac L-type Ca current to suppress early afterdepolarizations
Early afterdepolarizations (EADs) are arrhythmogenic membrane potential oscillations that occur before repolarization of the cardiac action potential (AP) is complete. Although the mechanistic link between EADs in single cells and triggered arrhythmias in the heart is still a subject of intense investigation (Wit and Rosen, 1983; Rosen, 1988; Antzelevitch and Sicouri, 1994; El-Sherif et al., 19...
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Unlike the brief action potentials (APs) in skeletal myo cytes or neurons, the human cardiac AP takes 100s of milliseconds to repolarize the cell. This slow repolar ization is essential for proper excitation–contraction coupling in cardiac muscle, and precise control of AP duration contributes to electrical stability. Under vari ous pathological conditions, often when the AP dura tion is pr...
متن کاملThe Skeletal L-type Ca2+ Current Is a Major Contributor to Excitation-coupled Ca2+ entry
The term excitation-coupled Ca(2+) entry (ECCE) designates the entry of extracellular Ca(2+) into skeletal muscle cells, which occurs in response to prolonged depolarization or pulse trains and depends on the presence of both the 1,4-dihydropyridine receptor (DHPR) in the plasma membrane and the type 1 ryanodine receptor in the sarcoplasmic reticulum (SR) membrane. The ECCE pathway is blocked b...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.1646